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KMID : 0376219730100010195
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Chonnam Medical Journal
1973 Volume.10 No. 1 p.195 ~ p.209
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Experimental Study on the Effect of Irradlation((137)^Cs) on the Homologous Bone Graft
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Abstract
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In an attempt to investigate the effect of irradiation on the homologous bone graft, the implantation was done to the proximal tibia of normal rabbit after irradiation of 137Cs in doses indicated to the donor bone fragment and the recipient site and for ten weeks period their radiological and histological findings were evaluated in comparison with those of normal autogenous and fresh homologous bone graft.
Followings were the results of this experiment
1. Auto graft group showed, radio logically, complete osseous union after seven weeks. Histologically the newly formed cartilage and callus was evident after one week with mild inflammatory reaction, resumed proliferation, and after seven weeks healing was completed as the callus was being- replaced by osseous tissue.
2. Fresh homograft showed, radiologically pronounced periosteal -reaction for three weeks, then decreased density of the implant, and osseous union after ten weeks. Histologically, the inflammatory reaction after one week was more evident than that of the auto graft group, necrosis and resorption of the implant began after two weeks being replaced by the proliferation of the donor site after seven weeks, when the healing became almost complete.
3. Homograft following irradiation(870R) to recipient site showed, radiologically, almost similar findings to that of fresh homograft except the periosteal reaction was less evident, resorption delayed and therefore healing prolonged. Histologically the process was comparable with that of fresh homograft, though inflammatory reaction was less evident and callus was more abundant even after ten weeks.
4. Homograft following irradiation of the implant resulted, radiologically, in healing after ten weeks, though apparently incomplete and this could be confirmed histologically in that healing was definitely retarded, compared with that of the fresh homograft as resorption and replacement still persisted even after ten weeks.
5. Homograft following irradiation(2,000R) to the implant showed, radiologically, remarkable retardation of both resorption and appearance of periosteal reaction and consequently incomplete healing after ten weeks. Histologically characteristic was the absence of any proliferation from the implant which immediately fell into necrosis and resorption, eventually being replaced by the proliferative process from the host site, and by tenth week there still persisted the abundant callus, substantiating delayed healing.
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